- HDAC inhibitors
Histone deacetylases (HDAC) are enzymes, which play an important role in the modification of histones.
They are involved in different biological pathways in the cell cycle.
The unique function of HDAC inhibitors is to modulate the expression of multiple genes and pathways.
By modulating genes associated with cellular apoptosis and cell proliferation, these agents may have utility in combination with cancer therapy.
Our HDAC inhibitors are versatile tools in basic research for the investigation of the cell cycle and in screening assay for novel anticancer drugs.
- DPP-4 inhibitors
Dipeptidyl peptidase-4 (DPP-4) plays a major role in glucose metabolism. Inhibition of the DPP-4 enzyme prolongs and enhances the activity of incretins that play an iportant role in insulin secreteion and blood glucose regulation.
DPP-4 is a target for the treatment of type 2 diabetes.
EMC DPP-4 inhibitors DPP-001 - DPP-003 show a very high selectivity against DPP-4 in comparison to DPP-8.